TABLE 2.
UPR target genes induced by XBP-1s
| Fold change in expression with: | GenBank no. | Description | ||
|---|---|---|---|---|
| XBP-1s | WT | XBP-1−/− | ||
| 5.7 | 9.6 | NC | AI835630 | ERdj4 |
| 2.9 | ∼4.0 | NC | AW212878 | EDEM |
| 2.7 | 3.6 | 3.1 | AW122364 | Armet |
| 2.7 | 3.3 | NC | AI604013 | p58IPK |
| 3.2 | 2.7 | NC | U28423 | p58IPK |
| 2.2 | 1.7 | NC | AW045202 | PDI-P5 |
| 2.1 | 1.5 | NC | AI843466 | Ramp4 |
| 1.9 | 2.1 | NC | AW122551 | HEDJ |
| 2.2 | 4 | NC | AW123880 | XBP-1 |
| 1.8 | 1.7 | NC | AI117848 | mgat2 |
| 3.2 | 11 | 7.2 | AI846938 | Herp |
| 2.4 | 7.4 | 2 | D16333 | Coproporphyrinogen oxidase |
| 2 | 8.8 | ∼15.0 | AW124049 | EST |
| 1.9 | 4.6 | NC | AI845538 | MGP |
| 1.5 | 2.4 | NC | AI843342 | Splicing factor, arginine/serine-rich 1 |
| 1.9 | 1.7 | NC | AV318100 | Similar to glucosidase 1 |
| 1.7 | 1.9 | NC | M22998 | Solute carrier family 2, member 1 |
| 1.6 | 1.6 | NC | M73329 | Phospholipase Cα |
| 1.6 | 1.6 | NC | AI839280 | RIKEN cDNA 1810045K07 gene |
| 1.5 | 2.5 | NC | AW123026 | Glucosamine-phosphate N-acetyltransferase 1 |
| 2.1 | 1.5 | 2.2 | X83601 | Pentaxin related gene |
| 1.7 | 4.5 | 2.8 | AJ002387 | BiP |
| 1.6 | 1.9 | NC | AA170696 | Intercellular adhesion molecule |
| 1.6 | 2.2 | NC | AI316859 | Hypothetical protein LOC223770, BR-140L |
| 1.5 | 2.9 | 2.3 | V00756 | Interferon-related developmental regulator 1 |
| 1.5 | 1.8 | NC | X92665 | Ubiquitin-conjugating enzyme E2E 1 |
a
Genes that were induced by doxycycline removal in MEF-tet-off-XBP-1s cells, as well as by Tm treatment in wt MEF cells are shown. Genes were sorted by ratio of positive oligonucleotide probe pairs upon doxycycline removal in MEF-tet-off-XBP-1s cells, and the genes that were as also inducible by Tm in wt cells are shown. Values represent the fold changes in expression level. NC, no change.