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Delayed replication is present in untransformed cells derived from fragile X patients. Replication patterns of Xq27 STSs are shown for fibroblasts (A) and mitogen-stimulated peripheral lymphocytes (B) that were derived from normal and fragile X males to examine further the delayed replication domain on fragile X chromosomes. Delayed replication was observed in all the fragile X cultures (arrows indicate strong replication delay).
