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. 2007 Oct 31;104(45):17735–17740. doi: 10.1073/pnas.0700724104

Fig. 6.

Fig. 6.

Haplotype map and expressed isoforms of the murine Ugt1a1 gene. (A) Of 274 SNPs within the Ugt1a1 locus, the nine exonic SNPs that alter an amino acid in the predicted protein are shown. The 15 inbred strains have two haplotypes within the 168.2-kb Ugt1a1 locus on chromosome 1. However, polymorphisms in the SMJ strain created a third haplotype in part of this locus. Each column represents an inbred mouse strain, and each box indicates the corresponding allele for that strain, and the first column indicates the amino acid substitution caused by the polymorphism. The allele indicated by a yellow box corresponds to the amino acid indicated in red, whereas a blue box indicates the amino acid shown in blue. A gray box indicates an unknown allele is for that strain. (B) The five different mRNA isoforms encoded by nine exons within mouse Ugt1a locus. Each isoform is generated by alternative splicing of one of the first five exons, and all expressed isoforms share four common exons (exons 6–9). All nine SNPs that alter the amino acid sequence of the protein are located within the first two exons. Ugt1a9 mRNA contains exon 1, whereas Ugt1a7c mRNA contains exon 2.