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Sequence motif conservation and active-site geometry. (A) Class-specific sequence motif completely conserved in class I. Conservation is generally high also within class II, with the notable exception of class IIa. (B) Active-site region of a bacterial class II homolog. To substitute Y as transition-state stabilizer, the H has to move closer to the active site. The LEGGY motif is indicated, as is the interaction between the Y and a representative hydroxamic acid moiety (INH).
