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The HDAC4 H976Y substitution generates a gain-of-function mutant. (A) Comparison of the enzymatic activities exhibited by WT, H976F-mutated, and H976Y-mutated HDAC4-FLAG proteins immunopurified from mammalian cells. (B) Comparison of the enzymatic activities of WT and H976Y-mutated HDAC4-CD proteins purified from E. coli. Data obtained on acetylated histones are shown.
