Figure 5.

LNC proliferative responses to mAb 5G12 in mice injected i.p. with the CDR-based peptides. LNC were taken from BALB/c (a) or SJL (b) mice treated with either pCDR1 (a) or pCDR3 (b). Proliferation is shown to mAb 5G12 of LNC taken from mice that were immunized and not treated (▪), mice treated concomitant with immunization with peptide p307 (┌) or with the CDR-based peptides (□). Proliferation is also shown to the immunodominant CDR-based peptide of LNC taken from nontreated mice (•) or of mice treated with the peptide (○). LNC proliferation was then carried out as described. Results are expressed as mean cpm of triplicates. SD values did not exceed 10%.