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Model of chemokine induced T-cell adhesion through LFA-1 and VLA-4. Chemokine-dependent G-protein-coupled-receptor signaling leads to activation of PLCγ. PLCγ products Ca2+ and DAG activate CalDAG-GEFI. This leads to Rap1 activation, which triggers inside-out activation of LFA-1 to promote T-cell adhesion. SDF-1α activates VLA-4 through PLCγ. PLCγ-generated products may promote PKC activation and subsequent integrin activation through unknown intermediates.
