Table 8.
Published gene signaturesa | ||||||
Pathways | GO_ID | Wang | Van 't Veer | Paik | Yu | Sotiriou |
ER-positive tumors | ||||||
Apoptosis | 6915 | X | X | X | X | X |
Regulation of cell cycle | 74 | X | X | X | X | X |
Protein amino acid phosphorylation | 6468 | X | X | X | X | X |
Cytokinesis | 910 | X | X | X | X | |
Cell motility | 6928 | X | X | |||
Cell cycle | 7049 | X | X | X | X | X |
Cell surface receptor-linked signal transd. | 7166 | X | ||||
Mitosis | 7067 | X | X | X | X | X |
Intracellular protein transport | 6886 | X | X | X | ||
Mitotic chromosome segregation | 70 | X | X | X | ||
Ubiquitin-dependent protein catabolism | 6511 | X | X | X | ||
DNA repair | 6281 | X | X | X | X | |
Induction of apoptosis | 6917 | X | ||||
Immune response | 6955 | X | X | X | ||
Protein biosynthesis | 6412 | X | X | X | ||
DNA replication | 6260 | X | X | X | X | |
Oncogenesis | 7048 | X | X | X | ||
Metabolism | 8152 | X | X | |||
Cellular defense response | 6968 | X | X | X | ||
Chemotaxis | 6935 | X | X | |||
ER-negative tumors | ||||||
Regulation of cell growth | 1558 | X | ||||
Regul. of G-coupled receptor signaling | 8277 | |||||
Skeletal development | 1501 | X | X | |||
Protein amino acid phosphorylation | 6468 | X | X | X | X | X |
Cell adhesion | 7155 | X | X | X | X | |
Carbohydrate metabolism | 5975 | X | X | |||
Nuclear mRNA splicing, via spliceosome | 398 | |||||
Signal transduction | 7165 | X | X | X | X | |
Cation transport | 6812 | |||||
Calciumion transport | 6816 | |||||
Protein modification | 6464 | |||||
Intracellular signaling cascade | 7242 | X | X | X | X | |
mRNA processing | 6397 | |||||
RNA splicing | 8380 | |||||
Endocytosis | 6897 | |||||
Regul. of transcription from PolII promoter | 6357 | X | ||||
Regulation of cell cycle | 74 | X | X | X | ||
Protein complex assembly | 6461 | X | X | |||
Protein biosynthesis | 6412 | X | X | |||
Cell cycle | 7049 | X | X | X | X | X |
aPublished gene signatures that were studied include the 76-gene signature [8], the 70-gene signature [3], the 16-gene signature [25], the 62-gene signature [26], and the 97-gene signature [23]. Individual genes in each signature were mapped to the top 20 core pathways for ER-positive and ER-negative tumors, a cross indicates a match.