Table 1 Brain areas of significant activation during the sex discrimination, semantic decision and finger‐tapping tasks in normal volunteers and the patient with pathological laughing before and after treatment.
| Normal group | The patient with pathological laughing | |
|---|---|---|
| Without paroxetine | With paroxetine | |
| (A) The sex discrimination task (12 normal volunteers and the patient) | ||
| Rt. Fusiform gyrus | Pons | Lt. fusiform gyrus |
| (40, −78, −16) | (6, −36, −22) | (−38, −42, −28) |
| (Z = 5.55) | (Z = 5.27) | (Z = 7.46) |
| Lt. Fusiform gyrus | Lt. fusiform gyrus | Lt. inferior temporal gyrus |
| (−38, −76, −16) | (−38, −42, −28) | (−40, −66, −2) |
| (Z = 4.85) | (Z = 8.00) | (Z = 4.38) |
| Rt. amygdala | Lt. amygdala | |
| (16, −6, −18) | (−22, −10, −14) | |
| (Z = 4.33) | (Z = 5.78) | |
| Lt. amygdala | Lt. inferior temporal gyrus | |
| (−16, −6, −18) | (−40, −68, 2) | |
| (Z = 4.47) | (Z = 5.15) | |
| Rt. inferiot frontal gyrus | Rt. cerebellum (MCP) | |
| (46, 14, 26) | (12, −40, −30) | |
| (Z = 5.57) | (Z = 4.63) | |
| Lt. middle frontal gyrus | Lt. cerebellum (MCP) | |
| (−36, 8, 34) | (−8, −42, −38) | |
| (Z = 4.20) | (Z = 4.40) | |
| Rt. hippocampus | ||
| (34, −16, −16) | ||
| (Z = 4.05) | ||
| Rt. lingual gyrus | ||
| (22, −70, 2) | ||
| (Z = 4.17) | ||
| (B) The semantic decision task (11 normal volunteers and the patient) | ||
| Rt. lingual gyrus | Pons | Rt. lingual gyrus |
| (32, −80, −20) | (2, −34, −32) | (22, −72, −18) |
| (Z = 5.76) | (Z = 4.35) | (Z = 7.37) |
| Lt. lingual gyrus | Rt. lingual gyrus | Lt. lingual gyrus |
| (−10, −90, −14) | (18, −90, −10) | (−22, −82, −22) |
| (Z = 7.62) | (Z = 7.35) | (Z = 8.00) |
| Lt. Fusiform gyrus | Lt. lingual gyrus | Rt. superior parietal lobe |
| (−38, −74, −16) | (−16, −86, −14) | (28, −74, 22) |
| (Z = 7.72) | (Z = 8.00) | (Z = 7.04) |
| Lt. inferior frontal gyrus | Rt. superior parietal lobe | Lt. superior parietal lobe |
| (−52, 28, 32) | (28, −74, 18) | (−20, −68, 38) |
| (Z = 5.72) | (Z = 4.95) | (Z = 7.82) |
| Rt. postcentral gyrus | Lt. superior parietal lobe | Rt. inferior temporal gyrus |
| (52, −14, 40) | (−22, −66, 26) | (54, −40, −14) |
| (Z = 4.75) | (Z = 6.05) | (Z = 4.54) |
| Lt. postcentral gyrus | Lt. inferior temporal gyrus | Lt. inferior temporal gyrus |
| (−44, −28, 58) | (−56, −42, −14) | (−54, −44, −22) |
| (Z = 5.36) | (Z = 6.09) | (Z = 7.38) |
| Rt. middle frontal gyrus | Lt. middle temporal gyrus | Rt. middle temporal gyrus |
| (42, 10, 52) | (−44, −36, −4) | (44, −28, −10) |
| (Z = 4.56) | (Z = 7.01) | (Z = 4.45) |
| Rt. Superior parietal lobe | Rt. inferior frontal gyrus | Lt. middle temporal gyrus |
| (14, −54, 54) | (26, 32, −18) | (−44, −36, −8) |
| (Z = 4.53) | (Z = 3.72) | (Z = 7.15) |
| Rt. cerebellum | Lt. middle frontal gyrus | Rt. inferior frontal gyrus |
| (20, −72, −18) | (−44, 6, 50) | (38, −12, 30) |
| (Z = 3.90) | (Z = 7.09) | (Z = 4.30) |
| Lt. inferior frontal gyrus | Lt. middle frontal gyrus | |
| (−26, 30, −14) | (−26, 0, 28) | |
| (Z = 5.52) | (Z = 8.00) | |
| Lt. supplementary motor area | Rt. cerebellum | |
| (−8, 10, 60) | (24, −56, −32) | |
| (Z = 5.88) | (Z = 8.00) | |
| Rt. precentral gyrus | Lt. cerebellum | |
| (60, −4, 32) | (−24, −52, −34) | |
| (Z = 5.79) | (Z = 6.36) | |
| Rt. cerebellum | ||
| (22, −72, −40) | ||
| (Z = 5.90) | ||
| (C) The finger‐tapping task (six normal volunteers and the patient) | ||
| Lt. precentral gyrus | Pons | Rt. precentral gyrus |
| (−24, −30, 66) | (−6, −36, −38) | (62, 2, 24) |
| (Z = 4.59) | (Z = 5.22) | (Z = 5.70) |
| Lt. Superior temporal gyrus | Rt. precentral gyrus | Lt. precentral gyrus |
| (−52, 8, 10) | (60, −4, 28) | (−30, −10, 64) |
| (Z = 3.62) | (Z = 5.25) | (Z = 6.88) |
| Lt. supplementary motor area | Lt. precentral gyrus | Lt. supplementary motor area |
| (−6, −6, 68) | (−30, −24, 42) | (−8, 2 84) |
| (Z = 4.22) | (Z = 6.94) | (Z = 5.66) |
| Rt. cerebellum | Lt. inferior temporal gyrus | Lt. anterior cingulate |
| (22, −50, −20) | (−40, −14, −26) | (−6, −12 50) |
| (Z = 3.98) | (Z = 5.92) | (Z = 5.22) |
| Lt. superior temporal gyrus | Lt. inferior frontal gyrus | |
| (−58, −26, 22) | (−48, 10, 28) | |
| (Z = 5.36) | (Z = 5.01) | |
| Rt. lingual gyrus | Rt. cerebellum | |
| (18, −88, −6) | (28, −50, −28) | |
| (Z = 5.93) | (Z = 6.40) | |
| Rt. superior frontal gyrus | ||
| (20, 66 26) | ||
| (Z = 5.04) | ||
| Rt. superior occipital gyrus | ||
| (36, −74, 10) | ||
| (Z = 4.95) | ||
| Rt. cerebellum | ||
| (20, −56, −30) | ||
| (Z = 7.44) | ||
| Lt. cerebellum | ||
| (−20, −52, −32) | ||
| (Z = 8.00) | ||
MCP, middle cerebellar peduncle; Rt., right; Lt, left.