Table 1 CTSD genotype and allele frequencies in 560 AD and 767 control subjects.
| Cohort | n | CTSD genotypes, n (%) | Alleles | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CC | CT | TT | C | T | ||||||||
| All AD | 560 | 475 (84.9) | 79 (14.1) | 6 (1.1) | 1029 (91.9) | 91 (8.1) | ||||||
| EOAD | 317 | 270 (85.1) | 44 (13.6) | 3 (1.0) | 574 (92.2) | 50 (7.8) | ||||||
| LOAD | 243 | 205 (84.3) | 35 (14.4) | 3 (1.3) | 445 (91.6) | 41 (8.4) | ||||||
| All controls | 767 | 648 (84.5) | 117 (15.3) | 2 (0.3) | 1413 (92.0) | 121 (8.0) | ||||||
| Younger controls | 496 | 422 (85.1) | 73 (14.7) | 1 (0.2) | 917 (92.4) | 75 (7.6) | ||||||
| Older controls | 270 | 225 (83.3) | 44 (16.3) | 1 (0.4) | 494 (91.5) | 46 (8.5) | ||||||
The AD group was stratified into EOAD and LOAD cohorts and the control group into younger and older control groups.