Table 1 APOE genotype and allele frequencies for 198 cases of frontotemporal lobar degeneration, overall and stratified by sex and necropsy confirmation, and 756 control cases, overall and stratified by sex.
| Patient group | APOE genotype | Allele frequency | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ε2/ε2 | ε2/ε3 | ε2/ε4 | ε3/ε3 | ε3/ε4 | ε4/ε4 | ε2 | ε3 | ε4 | ||
| FTLD | ||||||||||
| All patients (198) | 1 | 20 | 2 | 111 | 53 | 11 | 6.1 | 74.5 | 19.4 | |
| Male (103) | 0 | 9 | 1 | 55 | 31 | 7 | 4.9 | 72.3 | 22.3 | |
| Female (95) | 1 | 11 | 1 | 56 | 22 | 4 | 7.4 | 76.3 | 16.3 | |
| Confirmed (50) | 1 | 4 | 0 | 30 | 13 | 2 | 6.0 | 77.0 | 17.0 | |
| Unconfirmed (148) | 0 | 16 | 2 | 81 | 40 | 9 | 6.1 | 73.6 | 20.3 | |
| Controls | ||||||||||
| All (756) | 2 | 108 | 15 | 445 | 174 | 12 | 8.4 | 77.5 | 14.1 | |
| Male (227) | 2 | 34 | 5 | 136 | 49 | 1 | 9.5 | 78.2 | 12.3 | |
| Female (529) | 0 | 74 | 10 | 309 | 125 | 11 | 7.9 | 77.2 | 14.8 | |
Numbers of cases are given in parentheses.
FTLD, frontotemporal lobar degeneration.