Table 3 Characteristics of patients with parkinsonism.
Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | Patient 6 | Patient 7 | Patient 8 | Patient 9 | |
---|---|---|---|---|---|---|---|---|---|
Age (years) | 55 | 49 | 42 | 43 | 44 | 61 | 39 | 29 | 51 |
Age at diagnosis of epilepsy (years) | 46 | 27 | 7 | 27 | Birth | 53 | 5 | 23 | Late teens |
Sex | F | M | M | M | F | F | F | F | M |
Anticonvulsant drugs at time of assessment | Carbamazepine, lamotrigine | Lamotrigine | Vigabatrin, zonisamide | Valproate, clobazam | Valproate | Valproate, gabapentin | Valproate | Valproate, carbamazepine | Valproate |
UPDRS* | 10.5 | 13 | 11 | 13 | 14 | 15 | 16 | 16.5 | 18 |
Duration on VPA (years) | 2 | 7 | 4 | 2 | 13 | 16 | |||
Other movement disorders | Postural tremor | Postural tremor | Postural tremor | Postural tremor, dystonia | Postural tremor | Postural tremor | |||
Other features of potential importance | Retinitis pigmentosa | Taking risperidone for 3 months at the time of assessment | Atypical tremor with variability and distractibility | Coeliac disease diagnosed 6 months before onset of seizures | Cerebral palsy with mild left sided hemiparesis; left limbs smaller than right | Neurofibromatosis; | |||
Acute onset, progressive cognitive decline 2 years after starting valproate | |||||||||
Seizure type | Complex partial | Complex partial | Complex partial | Simple partial with secondary generalisation | Complex partial | Unclassified | Complex partial | Complex partial | Primary generalised |
F, female; M, male; UPDRS, Unified Parkinson's Disease Rating Scale; VPA, valproate .
*Modified UPDRS III (all items of UPDRS III were assessed, but only the most involved hemibody (upper and lower limbs) was recorded for items 20, 21, 22, 23, 24, 25 and 26 for a total maximum score of 56).