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. 2006 Mar;77(3):397–401. doi: 10.1136/jnnp.2005.073239

Table 1 Diagnoses for all hospitals combined, before (173 patients) and after (137 patients) guideline implementation.

Before After Difference* (95% CI) p Value
Diagnosis†
 Diabetes mellitus 32% 26% 0.21
 Alcohol abuse 14% 6% 0.02
 Vitamin deficiency or abuse 6% 9% 0.31
 Chronic renal disease 2% 4% 0.35
 Medication or toxic 2% 3% 0.70
 Hypothyroidism 2% 3% 0.70
 Paraproteinaemia 9% 9% 0.84
 Hereditary neuropathy 3% 7% 0.29
 Autoimmune or systemic disease 4% 4% 1.00
 CIDP 2% 4% 0.51
 Malignancy 2% 3% 0.70
 Idiopathic 43% 49% 0.36
Type of polyneuropathy
 Axonal 57% 55% 0.82
 Demyelinating 13% 12% 1.00
 Not specified‡ 31% 33% 0.71
Number of consultations/patient§ 4 (1) 4 (2) 0.1 (−0.3 to 0.5) 0.56
Time to diagnosis/patient (months)§ 3.5 (2.4) 2.7 (2.5) −0.4 (−1.0 to 0.1) 0.15
Repeated investigations 30% 34% 0.54

CI, confidence interval; CIDP, chronic inflammatory demyelinating polyradiculoneuropathy; UMCU, University Medical Centre Utrecht.

*Mean difference for the number of consultations and the time to diagnosis; †multiple diagnoses possible; ‡all in general hospitals, not in UMCU; §mean (SD).