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. 2006 Mar;77(3):397–401. doi: 10.1136/jnnp.2005.073239

Table 2 Number and costs of investigations for all hospitals combined, costs before (173 patients) and after (137 patients) guideline implementation.

Test Number of investigations/patient Costs (in €) of investigations/patient
Before After Difference* (95% CI) p Value Before After Difference* (95% CI) p Value
Electrolytes and glucose 3 (3) 2 (2) −42% (−60% to −23%) < 0.01 4.43 (4.61) 2.46 (3.28) −43% (−62% to −24%) < 0.01
Haematological tests† 4 (3) 2 (3) −37% (−57% to −18%) < 0.01 4.71 (4.43) 2.98 (3.97) −37% (−57% to −17%) < 0.01
Renal and liver function tests 4 (4) 2 (3) −48% (−68% to −29%) < 0.01 7.81 (7.84) 3.75 (5.93) −52% (−72% to −32%) < 0.01
Vitamins 1 (1) 1 (1) −2% (−29% to 24%) 0.87 8.29 (9.68) 8.13 (9.79) −2% (−28% to 24%) 0.88
Endocrinological tests‡ 1 (0.8) 1 (0.7) 4% (−29% to 37%) 0.80 3.54 (5.32) 3.67 (4.71) 4% (−28% to 24%) 0.82
Other laboratory tests§ 3 (4) 3 (4) 11% (−12% to 33%) 0.35 55.14 (134.85) 63.45 (133.35) 15% (−40% to 70%) 0.59
Electrophysiological examinations¶ 1.8 (0.72) 2.0 (0.80) 14% (4% to 24%) 0.01 131.97 (54.93) 150.09 (59.62) 14% (4% to 23%) < 0.01

Values are mean (SD).

*Mean relative difference for the number and costs of investigations; †includes full blood count, indices, and erythrocyte sedimentation rate; ‡includes thyroid funtion tests; §includes immunological tests, neuronal antibody tests, serological tests, and cerebrospinal fluid investigations; ¶electromyography, nerve conduction, and other neurophysiological investigations.

CI, confidence interval.