Figure 1 Axial fluid‐attenuated inversion recovery images of three patients with neuromyelitis optica‐IgG. (A–C) Case 1 developed extensive lesions in the brainstem, bilateral internal capsules, bilateral superior longitudinal fasciculus, corpus callosum and frontal white matter. None of these lesions showed gadolinium enhancement. (D–F) In the fourth relapse of case 2, a continuous lesion extended from the right edge of the pons to the centrum semiovale through the internal capsule and the superior longitudinal fasciculus. A symmetric lesion extending from the left side of the pons to the internal capsule appeared at the third relapse. Lesions were also seen at the cerebellum, corpus callosum and periventricular white matter. (G) Case 3 developed an asymptomatic hypothalamic lesion adjacent to the third ventricle, and the patient had visual impairment due to involvement of the optic chiasm by the lesion.