Figure 4.
Effect of analogues of C16:0-ceramide on raft stability as assessed from the effect of temperature on quenching of Lc-TMADPH by Tempo. Vesicles were composed of 19.5:18:37.5:25 SM:ceramide analogue:DOPC:chol. Key: compound 7 (plus sign), compound 8 (triangle), compound 9 (open circle), compound 10 (square), compound 11 (inverted triangle) and C16:0 cer (filled circle). Quenching curves for compounds 9 and 11 were assigned a limiting F/Fo value of 0.3 at high temperature. Results shown are the average values from duplicates. C16:0 = C16:0-ceramide