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Disruption of the Arf-Mdm2-p53 pathway in Eμ-Myc lymphomas. In Dmp1+/− and Dmp1−/− Eμ-Myc lymphomas, there is a striking reduction in the frequencies of p53 mutations and Arf deletions. This suggests that Dmp1 is a regulator of the Arf-p53 pathway in vivo.
