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. Author manuscript; available in PMC: 2007 Nov 14.
Published in final edited form as: Oncogene. 2007 Jan 22;26(30):4329–4335. doi: 10.1038/sj.onc.1210226

Figure 3.

Figure 3

Dmp1 links the Rb and p53 pathways. The novel ‘Jun-Dmp1’ pathway links oncogenic Ras-Raf signaling and the Arf-p53 pathway. This pathway is independent of the classical cyclin D1/Cdk4-Rb-E2F signaling. E2Fs directly bind to the Dmp1 promoter and causes repression; thus they have differential effects on the Dmp1 and on the Arf promoter. Overexpression of D-cyclins inhibits the activity of Dmp1 in a Cdk-independent fashion; however, on the Arf promoter, Dmp1 and cyclin D1 act synergistically, and this activity is dependent on Cdks. Dmp1 might have other targets than Arf, especially in T lymphocytes.