Epithelial cell proliferation and apoptosis in TRAMP prostates following castration. (A) The percent of proliferation in epithelial cells in each lobe of the prostate ▪ dorsal, □ lateral, and ventral. *P < .05: Days 4, 7, and 14 postcastration compared to sham-castrated animals in all lobes and Day 2 postcastration in the dorsal and ventral lobes only. (B) The percent of apoptosis in epithelial cells in each lobe of the prostate ▪ dorsal, □ lateral, and ventral. ***P < .001: Day 1 postcastration compared to sham-castrated animals in ventral lobe. **P < .01: Days 1 and 2 postcastration compared to sham-castrated animals in dorsal and lateral lobes. *P < .05: Day 4 postcastration compared to sham-castrated animals in dorsal and lateral lobes.