Table 2.
Incidence of Synaptophysin- or Foxa2-Expressing Cells in TRAMP Prostates.
| No Foci | Intraglandular Synaptophysin or Foxa2+, 1–2 Isolated Cells | Intraglandular Synaptophysin or Foxa2+, > 2 Cells (Foci) | Microscopic Tumor | Macroscopic Tumor | ||||||
| Intact | Cx | Intact | Cx | Intact | Cx | Intact | Cx | Intact | Cx | |
| No. of animals | 17 | 19 | 5 | 4 | 6 | 10 | 11 | 7 | 3 | 11 |
| Frequency of Synaptophysin+ or Foxa2+/Slide | 26/65 (0.4) | 33/82 (0.4) | 8/65 (0.12) | 9/82 (0.08) | 18/65 (0.28) | 16/82 (0.2) | 14/65 (0.22) | 9/82 (0.11) | 5/65 (0.08) | 17/82 (0.21) |
| No. of LN Metastasis/Animal-/+/NA | 8/1/8 | 9/1/9 | 2/0/3 | 1/0/3 | 5/1/0 | 7/1/2 | 3/0/8 | 4/0/3 | 0/3/0 | 3/4/4 |
| Frequency of Serotonin+/Foci | NA | NA | Not found on serial slides | 2/13 | 3/11 | 0 | 0 | 0 | 0 | |
| Frequency of Foxa2-/Foci | NA | NA | Not found on serial slides | 1/13 | 0 | 0 | 1/6 | 1/4 | 1/15 | |
| AR+/Foci | NA | NA | Not found on serial slides | 3/13 | 0 | 4/8 | 1/6 | 2/4 | 1/15 | |
There is a significant difference in the number of animals with different pathologies between intact and castrated (Cx) TRAMP in these defined categories with P < .05, chi-square analysis. The frequency of serotonin+, Foxa2-, and AR+ is per synaptophysin-expressing foci.