Table 3.
TNF308.2 Allele in Relation to Clinical Parameters in HCC Patients.
| Parameters | Group | n | With TNF308.2 Allele [n (%)] | P |
| Gender | Male | 77 | 17 (22.07) | NS |
| Female | 31 | 11 (35.48) | ||
| Age (years) | ≤ 50 | 44 | 9 (20.45) | NS |
| > 50 | 64 | 19 (29.68) | ||
| Cirrhosis | Yes | 91 | 28 (30.76) | .003 |
| No | 17 | 0 (0.00) | ||
| Child-Pugh | A* | 40 | 5 (12.50)†,‡ | .0001 |
| B* | 36 | 13 (36.11)† | ||
| C* | 15 | 10 (66.67)‡ | ||
| HBsAg/anti-HCV | Negative/negative | 11 | 3 (27.27) | NS |
| Negative/positive | 27 | 12 (44.44)§ | ||
| Positive/negative | 58 | 11 (18.96)§ | ||
| Positive/positive | 12 | 2 (16.67) | ||
| α-Fetoprotein (ng/ml) | ≤20 | 38 | 11 (28.94) | NS |
| > 20 | 70 | 17 (24.28) | ||
| AST (IU/l) | ≤40 (ULN) | 16 | 3 (18.75) | NS |
| > 40 | 92 | 25 (27.17) | ||
| ALT (IU/l) | ≤40 (ULN) | 19 | 0 (0.0) | .003 |
| > 40 | 89 | 28 (31.46) |
NS, not significant; ULN, upper limit of normal.
*
Pfor trend = .0001 (Mantel extension test for trend).
†
OR = 3.95; 95% CI = 1.10–14.89; P = .032.
‡
OR = 14.00; 95% CI = 2.80–78.00; P = .0002.
§
OR = 3.41; 95% CI = 1.12–10.56; P = .027.