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. 2007 Nov 16;3(11):e168. doi: 10.1371/journal.ppat.0030168

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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P₁ and P_1variants, and the P₂ and P_2variant, are each represented by one P₁ and P₂ schematic, respectively, for simplicity. Unique regions of sequence are indicated by variations of shading and patterns, e.g. D₁, P₁, D₄, P₂ all have the same pbp2x sequence (black), whereas R₁ has a different pbp2x sequence (speckled).

(A) Schematic of the recombinational crossover points revealed in the major group of progeny strains, ST695^19A. Three SNPs marked and confirmed the upstream crossover region and two SNPs marked and confirmed the downstream crossover region in the progeny strains, as shown with black arrows. The length of the recombinational fragment was 38.6 kb (10.3 kb upstream + 18.6 kb capsular locus + 9.7 kb downstream).

(B) Illustration of the second recombinational event. ST2365^19A is identical to ST645^19A in the entire sequenced region; no obvious crossover points have yet been revealed and the recipient is unknown.