Table 4 M4 receptor binding in the anterior and posterior striatum.
| M4 anterior M4 posterior | Control | PSP | LBD | AD |
|---|---|---|---|---|
| Caudate | 59.7 (0.1) | 47.3 (0.3) | 62.6 (0.2) | 54.7 (0.2) |
| 62.8 (0.1) | 30.7 (0.4)†§¶ | 62.7 (0.2) | 54.4 (0.2) | |
| Putamen | 56.8 (0.1) | 43.4 (0.4) | 56.3 (0.2) | 48.5 (0.2) |
| 52.5 (0.2) | 33.8 (0.3)*‡ | 54.8 (0.2) | 45.5 (0.2) | |
| GPe | 4.1 (0.3) | 5.7 (0.4) | 6.3 (0.3) | 7.4 (0.2) |
| 3.7 (0.3) | 4.4 (0.2) | 5.7 (0.2) | 5.0 (0.3) | |
| GPi | 6.3 (0.2) | 10.4 (0.1) | 3.6 (0.6) | 3.6 (0.7) |
| Insular cortex | 28.1 (0.1) | 23.6 (0.4) | 31.0 (0.4) | 24.9 (0.2) |
| 26.8 (0.2) | 17.9 (0.3)*§ | 32.0 (0.1) | 23.9 (0.2) |
AD, Alzheimer's disease; GPe, external globus pallidus; GPi, internal globus pallidus; LBD, Lewy body dementia; PSP, progressive supranuclear palsy.
Values expressed as geometric means (standard deviation) in fmol/mg.
Values in bold indicate M4 receptor binding in anterior striatum.
*Disease vs control p<0.05.
†Disease vs control p<0.001.
‡PSP vs LBD, p<0.05.
§PSP vs LBD, p<0.001.
¶PSP vs AD, p<0.01.