| Canada, workers (Horne, 2000)61
|
Case–control |
Occupational asthma |
HLAII‐DRB1: 27 alleles
HLAII‐DQB1: 14 alleles
(6p21,3) |
Western Red Cedar |
56/63 |
DQB1*0603: OR = 2.9 p = 0.0484
DQB1*0302: OR = 4.9 p = 0.02
DQB1*0501: OR = 0.3 p = 0.0213
DRB1*0401‐DQB1*0302: OR = 10.33 p = 0.012
DRB1*0101‐DQB1*0501: OR = 0.27 p = 0.038 |
| Platinum refinery workers exposed (Newman Taylor, 1999)64
|
Case–control |
Skin prick test positive to ACP |
HLAII‐DRB: 1 to 10
HLAII‐DPB: 1 to 10
HLAII‐DQA: 1 to 10
HLAII‐DQB: 1 to 10
(6p21,3) |
Ammonium hexachloroplatinate (ACP) |
44/57 |
HLADR3: OR = 2.3 (1.0–5.6)
HLADR6: OR = 0.4 (0.2–0.8)
These associations varies with intensity of exposure |
| UK, workers (Jeal, 2003)62
|
Case–control |
Sensitisation to rat lipocalin |
HLAII‐DQB1: 5 alleles
HLAII‐DRB1: 13 alleles
(6p21,3) |
Rat lipocalin allergens |
109/397 |
DR7: OR = 1.82 (1.12–2.97) sensitisation
DR7: OR = 2.96 (1.64–5.37) work‐related chest symptoms
DR7: OR = 3.81(1.90–7.65) sensitisation and work‐related chest symptoms
DR3: OR = 0.55 (0.31–0.97) sensitisation |
| Sweden, workers (Sjostedt, 1996)63
|
Case–control |
Occupational allergy |
HLA‐A
HLA‐BHLA‐C
HLA‐DR
(6p21,3) |
Laboratory animals |
92/27 |
Frequency cases v controls:
HLAII‐B16 0 v 30% |
| Austria and Germany, farmers children (Eder, 2004)86
|
Case–control |
Asthma
Atopy: IgE level ⩾3.5kU/l |
TLR2:
A‐16934T; C+596T;T+1349C
(9q32–q33)
TLR4:
A‐6143G;T‐5724C; A+4434G;G+7263C; T+8469C
(4q32) |
Farming endotoxin |
237/387 |
Frequency in exposed v controls
TLR2/−16934T:
3% v 16% p = 0.004 asthma
14% v 27% p = 0.023 atopy
3% v 14% p = 0.01 current hay fever |
