Table 4 Hazard ratio estimates of pancreatic cancer in relation to cumulative quantitative cotton dust and endotoxin exposures.

Exposure	Cases (n = 180)	Non‐cases (n = 3183)	HR*	95% CI	p for trend†
Cotton dust (mg/m3× years)
No lag
None	54	1016	1.0	Ref
>0 to 55.9	30	542	1.1	(0.7 to 1.7)
>55.9 to 97.0	27	542	0.9	(0.6 to 1.4)
>97.0 to 143.4	36	540	1.0	(0.6 to 1.6)
>143.4	33	543	0.9	(0.6 to 1.4)	0.60
10 year lag
None	55	1026	1.0	Ref
>0 to 55.9	33	611	1.1	(0.7 to 1.7)
>55.9 to 97.0	30	520	1.0	(0.6 to 1.6)
>97.0 to 143.4	30	509	0.8	(0.5 to 1.3)
>143.4	32	517	0.9	(0.6 to 1.4)	0.34
20 year lag
None	61	1198	1.0	Ref
>0 to 55.9	41	637	1.2	(0.8 to 1.8)
>55.9 to 97.0	31	455	1.0	(0.6 to 1.5)
>97.0 to 143.4	27	457	0.7	(0.5 to 1.2)
>143.4	20	436	0.6	(0.3 to 0.9)	0.006
Endotoxin (EU/m3× years)
No lag
None	54	916	1.0	Ref
>0 to 1517.4	32	530	1.0	(0.7 to 1.6)
>1517.4 to 2430.0	36	529	1.1	(0.7 to 1.6)
>2430.0 to 3530.6	24	530	0.6	(0.4 to 1.1)
>3530.6	30	529	0.8	(0.5 to 1.2)	0.12
10 year lag
None	55	926	1.0	Ref
>0 to 1517.4	36	627	1.1	(0.7 to 1.7)
>1517.4 to 2430.0	35	501	1.0	(0.7 to 1.6)
>2430.0 to 3530.6	23	479	0.6	(0.4 to 1.1)
>3530.6	27	501	0.7	(0.4 to 1.1)	0.04
20 year lag
None	61	1093	1.0	Ref
>0 to 1517.4	46	663	1.2	(0.8 to 1.8)
>1517.4 to 2430.0	35	462	1.0	(0.6 to 1.5)
>2430.0 to 3530.6	15	402	0.4	(0.2 to 0.8)
>3530.6	19	414	0.5	(0.3 to 0.9)	<0.001

*Age (continuous) and smoking status (categories) adjusted hazard ratio.

†Trend test for exposed women only.