Table 1.
Effects of high salt intake and ACE inhibitors on body weight and 24 h food and water intake in Dahl S rats
| Regular salt diet |
High salt diet |
|||
|---|---|---|---|---|
| Vehicle | Vehicle | Trandolapril | Lisinopril | |
| BW (g) | ||||
| 2 weeks | 213±2 | 179±3* | 200±3*† | 197±2*† |
| 4 weeks | 356±2 | 316±4* | 312±3* | 310±7* |
| Food intake (g 100 g−1 BW) | ||||
| Baseline | 11±1 | 12±1 | 12±1 | 12±1 |
| 1 week | 10±1 | 12±1 | 10±1 | 11±1 |
| 2 weeks | 9±1 | 11±1 | 9±1 | 9±1 |
| 3 weeks | 7±1 | 6±1 | 7±1 | 7±1 |
| 4 weeks | 8±1 | 8±1 | 8±1 | 7±1 |
| 5 weeks | 8±1 | 7±1 | 8±1 | 7±1 |
| Water intake (ml 100 g−1 BW) | ||||
| Baseline | 16±1 | 16±1 | 22±3*† | 22±2*† |
| 1 week | 15±1 | 57±2* | 57±1* | 57±2* |
| 2 weeks | 13±1 | 51±3* | 50±2* | 46±2* |
| 3 weeks | 10±1 | 34±1* | 42±2* | 43±3* |
| 4 weeks | 10±1 | 34±2* | 39±5* | 37±2* |
| 5 weeks | 9±1 | 34±2* | 36±2* | 37±2* |
Abbreviations: ACE, angiotensin-converting enzyme; BW, body weight.
Values are expressed as mean±s.e.mean, n=6 rats per group.
*P<0.05 vs regular salt. †P<0.05 vs high salt +vehicle.