Table 4.

AT₁ receptor densities in Dahl S rats treated with vehicle, lisinopril or trandolapril at two dose levels for 5 weeks

	Regular salt diet	High salt diet
	vehicle	Vehicle	Trandolapril		Lisinopril
			1	5	10		50 mg kg−1 per day
Brain nuclei outside the BBB
OVLT	830±18	932±7*	856±29	798±36†	839±12		814±23
SFO	1335±29	1617±39*	1251±24†	1265±23	1370±24†#	–a–	1293±32†
Brain nuclei inside BBB
MnPO	654±13	814±9*	747±18*†	738±27*†	768±11*		758±10*
PVN	812±5	1021±33*	911±17*†	887±24†	967±19*†	–a–	866±18†
Kidney
Medulla	2499±23	1772±40*	1902±14†	2014±51†	2004±27†		1932±24†
Cortex	1454±30	949±43*	1214±23†	1335±37†	1218±49†		1262±48†
Heart
LV	70±3	67±2	63±2	65±2	64±3		67±2
RV	18±1	17±1	16±1	16±1	16±1		17±1
LA	69±4	66±5	67±3	74±6	73±6		76±1
RA	56±2	72±4	63±4	65±2	57±4		63±4
Aorta	174±6	218±10*	166±6†	146±5†*	165±5†		160±5†

Abbreviations: BBB, blood–brain barrier; MnPO, median preoptic nucleus; OVLT, organum vasculosum laminae terminalis; PVN, paraventricular nucleus; SFO, subfornical organ.

Values are expressed as mean±s.e.mean of bound ¹²⁵I Angiotensin II (fmol mg⁻¹ wet tissue). n=6 rats per group.

^aP<0.05 between groups. ^*P<0.05 vs regular salt diet, ^†P<0.05 vs high salt+ vehicle, ^#P<0.05 vs corresponding values after trandolapril.