Table 5.

Left ventricular parameters by echocardiography in Dahl S rats after 2 and 4 weeks of high salt diet and ACE inhibitor treatment

		Regular salt diet	High salt diet
		vehicle	Vehicle	Trandolapril	Lisinopril
LVIDd
Absolute (mm)	2 weeks	6.3±0.2	6.3±0.1	6.1±0.2	5.8±0.1
	4 weeks	6.7±0.2	6.9±0.1	6.4±0.2	6.6±0.2
Relative (mm 100 g−1 BW)	2 weeks	3.0±0.1	3.5±0.1*	3.1±0.1	2.9±0.1†
	4 weeks	1.9±0.1	2.1±0.1*	1.9±0.1	2.0±0.1
LVIDs
Absolute (mm)	2 weeks	2.9±0.1	3.1±0.1	2.8±0.1	2.5±0.1†
	4 weeks	3.2±0.2	3.6±0.1	2.6±0.1*†	2.6±0.2*†
Relative (mm 100 g−1 BW)	2 weeks	1.4±0.1	1.9±0.1*	1.4±0.1†	1.3±0.1†
	4 weeks	0.9±0.1	1.1±0.1*	0.8±0.1†	0.8±0.1†
IVS+PW (d, mm)	2 weeks	2.3±0.1	2.7±0.1*	2.4±0.1†	2.4±0.1†
	4 weeks	2.6±0.1	3.5±0.1*	2.9±0.1*†	2.8±0.1†
Heart rate (b.p.m.)	2 weeks	350±12	407±3*	349±7†	356±8†
	4 weeks	373±6	431±10*	369±8†	379±9†
Ejection fraction (%)	2 weeks	83±2	79±2	84±1	86±1†
	4 weeks	82±2	74±3*	87±1†	88±2†
LV mass
Absolute (mg)	2 weeks	407±25	483±12*	405±13†	373±14†
	4 weeks	527±26	843±21*	563±28†	575±35†
Relative (mm 100 g−1 BW)	2 weeks	191±11	270±4*	203±8†	189±8†
	4 weeks	149±7	259±5*	170±10†	173±10†

Abbreviations: ACE, angiotensin-converting enzyme; BW, body weight; IVS, interventricular septum; LVID_d, left ventricular internal dimension in diastole; LVID_s, left ventricular internal dimension in systole; PW, posterior wall.

Values are expressed as mean±s.e.mean, n=6 rats per group. ^*P<0.05 vs regular salt. ^†P<0.05 vs high salt +vehicle.