. 2007 Sep 17;152(6):930–938. doi: 10.1038/sj.bjp.0707451

Table 2.

Pharmacokinetics of acemetacin

Drug measured	Route of administration of acemetacin	T_max (h)	C_max (μg ml⁻¹)	AUCt (μg h ml⁻¹)
Acemetacin	Oral	0.28±0.04	5.93±1.11	4.88±1.08
Acemetacin	Subcutaneous	0.18±0.04	10.44±1.09^*	10.83±2.11^*
Indomethacin	Oral	8.50±0.73	64.40±3.72	1193±51.32
Indomethacin	Subcutaneous	2.16±0.40^*	61.42±5.47	1115±63.66

Pharmacokinetic parameters for acemetacin and indomethacin were measured in plasma samples collected 5 min to 30 h after oral or subcutaneous administration of acemetacin (83.8 μmol kg⁻¹). Data are presented as mean±s.e.m. with eight rats per group. C_max is the maximal plasma concentration, T_max is the time to reach C_max, and AUC is the area under the plasma-against-time curve.

^*P⩽0.05 (Student's t-test) compared to the group given acemetacin orally.