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Halothane inhibition of 4AP-evoked glutamate and GABA release from wild-type littermate (WT) and TREK-1 knockout (KO) mouse cortical nerve terminals. IC50 values (mean±s.e.m.) were compared between glutamate and GABA release (***P<0.001), and between WT and KO mice (†††P<0.001) using the F-test (Prism 4.0). Shaded area highlights the clinical concentration range (0.5–2 times MAC) for WT mice (0.24 mM; Heurteaux et al., 2004).
