Table 1.

Effect of IL-12 Schedule on Suppression of P1A-Specific CTL Responses^a

	P1A cDNA	100 ng IL-12	Mean P1A-specific lysis (%)b	Range of lysis (%)
A	Days 0 and 7	None	39	36–47
B	Days 0 and 7	Day 0	10	6–19
C	Days 0 and 7	Day −1	4	2–17
D	Days 0 and 7	Day 1	23	10–37
E	Days 0 and 7	Days 1, 2, and 3	29	22–39
F	Days 0 and 7	Days −1 and 6	6	2–12
G	Days 0 and 7	Days 0 and 7	<5	0–4
H	Days 0 and 7	Days 1 and 8	9	3–22

^aP1A cDNA was administered by gene gun as described. 100 ng IL-12 was given s.c. at indicated times. Seven days after the last vaccination, splenocytes were restimulated in vitro as described and measured for P1A-specific CTL response.

^bMean P1A-specific lysis for 5 mice (groups A–E) or 3 mice (groups F–H).