Table 2 Analysis of genetic factors by case‐control status (all cases versus controls) after adjustment*.
| Genetic polymorphisms | Reference group | Studied groups | OR (95% CI) | p Value** |
|---|---|---|---|---|
| CYP2D6 | *1*1 | *1*4 | 0.90 (0.75 to 1.07) | 0.16** |
| *4*4 | 0.83 (0.55 to 1.26) | |||
| PON1 L55M | M/M | L/M | 0.92 (0.77 to 1.09) | 0.31** |
| L/L | 0.90 (0.69 to 1.18) | |||
| PON1 Q192R | Q/Q | Q/R | 0.99 (0.83 to 1.17) | 0.67** |
| R/R | 1.40 (0.83 to 1.57) | |||
| GSTM1 | Positive | Null | 1.12 (0.95 to 1.31) | 0.18 |
| GSTT1 | Positive | Null | 0.93 (0.75 to 1.56) | 0.52 |
| GSTM3 | AA | AB | 1.01 (0.84 to 1.20) | 0.54** |
| BB | 0.71 (0.42 to 1.22) | |||
| GSTP1 haplotype | AA | AB/AC/AD | 0.98 (0.82 to 1.16) | 0.74 |
| BB/BC/CC | 1.10 (0.83 to 1.47) | |||
| NQO1 | *1*1 | *1*2 | 0.95 (0.80 to 1.13) | 0.41** |
| *2*2 | 0.86 (0.55 to 1.34) | |||
| CYP1B1 | *1*1 | *1*3 | 0.95 (0.79 to 1.13) | 0.76** |
| *3*3 | 0.98 (0.77 to 1.24) | |||
| MAO‐A (males) | T | G | 1.30 (1.02 to 1.66) | 0.04 |
| MAO‐A (females) | TT | TG | 1.06 (0.82 to 1.36) | 0.55** |
| GG | 1.26 (0.72 to 1.76) | |||
| MAO‐B (males) | A | G | 1.09 (0.87 to 1.36) | 0.45 |
| MAO‐B (females) | AA | AG | 1.14 (0.86 to 1.51) | 0.49** |
| GG | 1.11 (0.79 to 1.56) | |||
| SOD2 Val9Ala | AA | AV | 1.00 (0.82 to 1.22) | 0.95** |
| VV | 0.99 (0.79 to 1.25) | |||
| EPHX3 Y113H† | YY | YH | 0.89 (0.71 to 1.13) | 0.28** |
| HH | 0.86 (0.61 to 1.21) | |||
| EPHX4 H139R | HH | HR | 0.95 (0.80 to 1.13) | 0.72** |
| RR | 1.37 (0.89 to 2.10) | |||
| DAT1 | A/A | A/G | 0.94 (0.80 to 1.12) | 0.93** |
| G/G | 1.13 (0.82 to 1.55) | |||
| DRD2A††† | CC | CT | 0.93 (0.74 to 1.16) | 0.26** |
| TT | 1.42 (1.00 to 2.03) | |||
| DRD2B† | B2B2 | B2B1 | 0.95 (0.77 to 1.67) | 0.97** |
| B1B1 | 1.27 (0.69 to 2.34) | |||
| NAT2 | Fast/fast | Fast/slow | 1.04 (0.87 to 1.24) | 0.97** |
| Slow/slow | 0.95 (0.71 to 1.26) |
*Logistic regression adjusting for age, sex, country, ever used tobacco containing product, ever knocked unconscious and first degree family history of Parkinson's disease. MAO‐A and MAO‐B are not adjusted for sex but are presented for males and females separately.
**For three category factors p value for trend derived from logistic regression coding genetic factors as 0, 1 and 2 variable.
†Malta excluded from analysis involving DRD2B.
††Sweden and Italy excluded from analysis involving EPHX3.
†††Sweden and Malta excluded from analysis involving DRD2A.