Table 2 Estimates for annual changes in FEV1 (ml/year) over 20 years in relation to endotoxin exposure by TNF polymorphisms*.
| Genotypes | n | Estimate (95% CI†) |
|---|---|---|
| TNF polymorphism | ||
| G/G | 422 | –2.87 (–5.31 to –0.43) |
| GA+AA | 71 | –6.83 (–13.32 to –0.34) |
| LTA polymorphism | ||
| A/A | 159 | –2.03 (–6.39 to 2.34) |
| A/G | 249 | –3.97 (–7.09 to –0.85) |
| G/G | 85 | –3.85 (–9.13 to 1.97) |
| A/G+G/G | 334 | –3.95 (–6.63 to –1.28) |
| Combined TNF and LTA polymorphisms‡ | ||
| Zero variant allele | 159 | –2.03 (–6.39 to 2.34) |
| One variant allele | 209 | –3.43 (–6.69 to –0.18) |
| Two or more variant alleles | 125 | –5.17 (–9.97 to –0.36) |
*Adjusting for age, smoking status, smoking amount and baseline FEV1.
†95% CI for tests that coefficients are different from zero.
‡Combined genotypes based on the number of variant alleles, with zero variant allele in the wild genotype (G/G of TNF and A/A of LTA), one variant allele in heterozygous genotype (G/A of TNF and A/G of LTA), and two or more variant alleles in homozygous genotype (A/A of TNF and G/G of LTA).