Table 3.
Homology relationships between the kinomes of S. cerevisiae, S. pombe and E. cuniculi
| AGC family | ||||
| Sub-family | S. cerevisiae | S. pombe | E. cuniculi | Deletion mutant |
| AKT | YPK1, YPK2 | SPCC24B10.07 (gad8) | Viable (Sc, Sp) | |
| AKT | SCH9 | SPAC1B9.02c (sck1), SPAC22E12.14c (sck2) | Viable (Sc, Sp) | |
| AUR | IPL1 | SPCC320.13c (ark1) | CAD25568.1 | Lethal (Sc, Sp) |
| BUB | BUB1 | SPCC1322.12c (bub1) | Viable (Sc, Sp) | |
| NDR | RIM15 | SPAPB18E9.02c (ppk18), SPCC1450.11c (cek1) | Viable (Sc, Sp) | |
| NDR | CBK1 | SPAC821.12 (orb6) | CAD25005.1 | Lethal (Sc, Sp) |
| NDR | DBF2, DBF20 | SPCC417.06c (ppk35), SPAC24B11.11c (sid2) | Lethal (sid2) | |
| PDK1 | PKH1, PKH2 | SPCC576.15c (ksg1) | Lethal (ksg1) | |
| PDK1 | YDR466W (PKH3) | SPBC1778.10c (ppk21) | Viable (Sc, Sp) | |
| PKA | TPK1, TPK2, TPK3 | SPBC106.10 (pka1) | CAD25584.1 | Viable (Sc, Sp) |
| PKC | PKC1 | SPAC17G8.14c (pck1), SPBC12D12.04c (pck2) | Lethal (PKC1) | |
| RSK | KIN82 | SPBC1861.09 (ppk22) | Viable (Sc, Sp) | |
| RSK | YNR047W | SPAC4G8.05 (ppk14) | Viable (Sc, Sp) | |
| RSK | YBR028C | SPCC4G3.08 (psk1) | Viable (Sc, Sp) | |
| AGC unpaired | AGC unpaired | AGC unpaired | ||
| YKL171W | SPBC725.06c (ppk31) | CAD25776.1 | ||
| SPCC162.10 (cmk2) | ||||
| CAMK family | ||||
| Sub-family | S. cerevisiae | S. pombe | E. cuniculi | Deletion mutant |
| CAMK1 | CMK1, CMK2 | SPACUNK12.02c (cmk1) | Viable (Sc, Sp) | |
| CAMK1 | RCK1, RCK2 | SPAC23A1.06c (cmk2), SPCC1322.08 (srk1) | Viable (Sc, Sp) | |
| CAMKK | TOS3, PAK1 | SPCC297.03 (ssp1), SPCC1919.01 (ppk34) | Viable (Sc, Sp) | |
| CAMKL | CHK1 | SPCC1259.13 (chk1) | CAD26208.1 | Viable (Sc, Sp) |
| CAMKL | KIN1, KIN2 | SPBC4F6.06 (kin1), SPBC32C12.03c (ppk25) | CAD26242.1, CAD26452.1 | Viable (Sc, Sp) |
| CAMKL | KIN4, YPL141C | SPAC110.01 (ppk1) | Viable (Sc, Sp) | |
| CAMKL | YPL150W | SPAC890.03 (ppk16) | Viable (Sc, Sp) | |
| CAMKL | FUN31, YOL045W | SPAC1805.01c (ppk6) | Viable (Sc, Sp) | |
| CAMKL | SNF1 | SPCC74.03c (ssp2), SPAC23H4.02 (ppk9) | Viable (Sc, Sp) | |
| CAMKL | KCC4, GIN4, HSL1 | SPAC644.06c (cdr1), SPAC57A10.02 (cdr2) | Viable (Sc, Sp) | |
| CAMK-Unique | MEK1 | SPAC14C4.03 (mek1) | Viable (Sc, Sp) | |
| CAMK-Unique | PRR1 | SPBC337.04 (ppk27) | Viable (Sc, Sp) | |
| HAL | SAT4 | SPAC29A4.16 (ppk10) | Viable (Sc, Sp) | |
| HAL | YOR267C, YDL025C | SPCC1020.10 (oca2) | Viable (Sc, Sp) | |
| RAD53 | RAD53 | SPCC18B5.11c (cds1) | Lethal (RAD53) | |
| RAN | KSP1 | SPBC16E9.13 (ppk20) | Viable (Sc, Sp) | |
| ULK | APG1 | SPCC63.08c (ppk36) | Viable (Sc, Sp) | |
| CAMK unpaired | CAMK unpaired | CAMK unpaired | ||
| (PTK1, PTK2) | SPAC22G7.08 (ppk8) | CAD26060.1 | ||
| (HAL5, KKQ8) | (SPCC70.05c (ppk37, Lethal), SPBC21.07c (ppk24)) | CAD25086.1 | ||
| DUN1 | SPBC19C2.05 | |||
| YMR291W | SPAC15A10.13 | |||
| (NPR1, PRR2) | SPBP23A10.10 | |||
| IKS1 | ||||
| YGR052W | ||||
| ISR1 | ||||
| CK1 family | ||||
| Sub-family | S. cerevisiae | S. pombe | E. cuniculi | Deletion mutant |
| CK1 | YCK1 | SPAC1805.05 (cki3) | ||
| CK1 | YCK2 | SPBC1347.06c (cki1) | ||
| CK1 | YCK3 | SPBP35G2.05c (cki2) | ||
| CK1 | HRR25 | SPBC3H7.15 (hhp1) | CAD26235.1 | Lethal (HRR25) |
| SPAC23C4.12 (hhp2) | CAD26108.1 | |||
| CMGC family | ||||
| Sub-family | S. cerevisiae | S. pombe | E. cuniculi | Deletion mutant |
| CDC7 | CDC7 | SPBC776.12c (hsk1), SPBC21C3.18 (spo4) | CAD26498.1, CAD25731.1 | Lethal (CDC7, hsk1) |
| CDK | KIN28 | SPBC19F8.07 (crk1) | CAD25174.1 | Lethal (KIN28, crk1) |
| CDK | CDC28 | SPBC11B10.09 (cdc2) | CAD26495.1 | Lethal (CDC28, cdc2) |
| CDK | CTK1 | SPAC2F3.15 (lsk1) | CAD26006.1 | Viable (Sc, Sp) |
| CDK | CAK1 | SPAC1D4.06c (csk1) | Lethal (CAK1) | |
| CDK | SGV1 | SPBC32H8.10 (cdk9) | Lethal (SGV1, cdk9) | |
| CDK | PHO85 | SPCC16C4.11 (pef1) | Viable (Sc, Sp) | |
| CDK | SSN3 | SPAC23H4.17c (srb10) | Viable (Sc, Sp) | |
| CK2 | CKA1, CKA2 | SPAC23C11.11 (cka1) | CAD26671.1 | Lethal (cka1) |
| CLK | KNS1 | SPAC1D4.11c (lkh1) | Viable (Sc, Sp) | |
| DYRK | YAK1 | SPAC823.03 (ppk15) | CAD25928.1 | Viable (Sc, Sp) |
| GSK | RIM11, MRK1 | SPBC8D2.01 (gsk31), SPAC1687.15 (gsk3) | Viable (Sc, Sp) | |
| MAPK | FUS3, KSS1 | SPAC31G5.09c (spk1) | Viable (Sc, Sp) | |
| MAPK | HOG1 | SPAC24B11.06c (sty1) | Viable (Sc, Sp) | |
| MAPK | SLT2, YKL161C | SPBC119.08 (pmk1) | Viable (Sc, Sp) | |
| RCK | IME2 | SPAC3C7.06c (pit1), SPBC8D2.19 (mde3) | Viable (Sc, Sp) | |
| SRPK | SKY1 | SPBC530.14c (dsk1) | Viable (Sc, Sp) | |
| TTK | MPS1 | SPBC106.01 (mph1) | CAD25082.1 | Lethal (MPS1) |
| CMGC unpaired | CMGC unpaired | CMGC unpaired | ||
| SMK1 | SPAC16C9.07 (ppk5), SPAC2F7.03c (pom1) | CAD25660.1 | ||
| (MCK1, YOL128C) | SPCC777.14 (prp4, Lethal) | (CAD26039.1, CAD26483.1) | ||
| SPBC336.14C | ||||
| SPBC18H10.15 (ppk23) | CAD26328.1 | |||
| STE family | ||||
| Sub-family | S. cerevisiae | S. pombe | E. cuniculi | Deletion mutant |
| STE7 | PBS2 | SPBC409.07c (wis1) | (none) | Viable (Sc, Sp) |
| STE7 | MKK1, MKK2 | SPBC543.07 (pek1) | Viable (Sc, Sp) | |
| STE7 | STE7 | SPAC1D4.13 (byr1) | Viable (Sc, Sp) | |
| STE20 | STE20 | SPBC1604.14c (shk1) | Lethal (shk1) | |
| STE20 | CLA4, SKM1 | SPAC1F5.09c (shk2) | Viable (Sc, Sp) | |
| STE20 | SPS1 | SPAC2C4.14c (ppk11), SPAC9G1.09 (sid1) | Lethal (sid1) | |
| STE20 | CDC15 | SPBC21.06c (cdc7) | Lethal (CDC15, cdc7) | |
| STE20 | KIC1 | SPBC17F3.02 (nak1) | Lethal (KIC1, nak1) | |
| STE11 | SSK2, SSK22 | SPAC1006.09 (win1), SPAC9G1.02 (wis4) | Viable (Sc, Sp) | |
| STE11 | STE11 | SPBC1D7.05 (byr2) | Viable (Sc, Sp) | |
| STE11 | BCK1 | SPAC1F3.02c (mkh1) | Viable (Sc, Sp) | |
| Other group | ||||
| Sub-family | S. cerevisiae | S. pombe | E. cuniculi | Deletion mutant |
| Bud32 | BUD32 | SPAP27G11.07c$$ | CAD25400.1 | Viable (BUD32) |
| GCN2 | GCN2 | SPAC20G4.03c (hri1) | Viable (Sc, Sp) | |
| IRE | IRE1 | SPAC167.01 (ppk4) | Viable (Sc, Sp) | |
| NAK | YPL236C | SPAC3H1.13 (ppk13) | Viable (Sc, Sp) | |
| NAK | AKL1, PRK1, ARK1 | SPCP1E11.02 (ppk38), SPBC6B1.02 (ppk30), SPBC557.04 (ppk29) | Viable (Sc, Sp) | |
| NEK | KIN3 | SPAC19E9.02 (fin1) | Viable (Sc, Sp) | |
| PLK | CDC5 | SPAC23C11.16 (plo1) | CAD24933.1 | Lethal (CDC5, plo1) |
| VPS15 | VPS15 | SPBC119.07 (ppk19) | Viable (Sc, Sp) | |
| WEE | SWE1 | SPCC18B5.03 (wee1), SPBC660.14 (mik1) | CAD26466.1 | Viable (Sc, Sp) |
| Other unpaired | Other unpaired | Other unpaired | ||
| SCY1 | SPBC15C4.02$$ | CAD26209.1 | ||
| ELM1 | SPAC12B10.14c (ppk2) | CAD26233.1 | ||
| SPAC23C4.03$$ | ||||
| SPAC222.07c (hri2) | ||||
| SPBC36B7.09 (ppk28) | ||||
| TKL family | S. cerevisiae | S. pombe | E. cuniculi | Deletion mutant |
| (none) | (none) | CAD26582.1 | Unknown | |
| PIKK family | S. cerevisiae | S. pombe | E. cuniculi | Deletion mutant |
| MEC1 | SPBC216.05 | |||
| TEL1 | SPCC23B6.03c * | CAD25142.1, CAD25955.1 | ||
| TOR1 | SPBC216.07c | |||
| TOR2 | SPBC30D10.10c | |||
| TRA1 | SPAC1F5.11c | |||
| RIO family | S. cerevisiae | S. pombe | E. cuniculi | |
| RIO1 | SPAC10F6.10 | |||
| RIO2 | SPBC1703.05 | CAD26627.1 | ||
| PDHK family | S. cerevisiae | S. pombe | E. cuniculi | |
| YGL059W | (none) | |||
| YIL042C | SPAC644.11c | |||
$$novel; no information on these S pombe kinases
* SPAC22E12.16c, SPBC577.06c, and SPAC458.05 are TEL1-related