TABLE 2.

Regional DV Values After Injection of (+)-¹¹C-McN5652 or ¹¹C-DASB

Radioligand*	Pons	MB	Hypo	Thalamus	Put	Cd	FC	PC	TC	CC	OC	Cereb
11C-McN5652
Control	29.4 ± 1.4	40.2 ± 2.7	46.1 ± 2.6	33.4 ± 1.2	23.6 ± 1.3	22.0 ± 1.4	12.9 ± 0.3	14.4 ± 0.5	15.5 ± 0.2	14.9 ± 0.5	14.3 ± 0.2	13.7 ± 0.3
MDMA	17.4 ± 1.2†‡	22.5 ± 2.5†	21.2 ± 2.4†‡	14.4 ± 0.6†‡	11.2 ± 0.7†‡	11.8 ± 0.9†‡	8.2 ± 0.6†‡	8.6 ± 0.4†‡	10.0 ± 0.8†‡	9.2 ± 0.3†‡	8.4 ± 0.4†‡	8.7 ± 0.4†‡
Paroxetine	14.8 ± 3.2†	15.3 ± 2.7†‡	15.3 ± 2.8†	16.9 ± 3.3†	18.3 ± 3.6	16.7 ± 3.1	13.2 ± 2.2	14.3 ± 2.4	15.1 ± 1.8	13.5 ± 2.5	14.3 ± 2.4	13.0 ± 2.3
11C-DASB
Control	46.2 ± 11.1	71.3 ± 14.8	79.8 ± 11.2	45.5 ± 4.5	22.2 ± 3.3	27.5 ± 2.7	9.8 ± 1.3	9.2 ± 1.0	11.6 ± 1.4	11.5 ± 1.4	9.0 ± 0.9	9.2 ± 0.7
MDMA	26.5 ± 2.7	31.3 ± 1.4	31.3 ± 5.6†	15.9 ± 1†‡	8.9 ± 0.9†	11.5 ± 0.9†	6.1 ± 0.2	5.9 ± 0.3†	7.2 ± 0.7	6.9 ± 0.3†	6.0 ± 0.3†	6.3 ± 0.4†
Paroxetine	7.7 ± 0.8†∥	7.9 ± 0.8†∥	8 ± 0.8†‡∥	8.3 ± 0.6†‡∥	7.9 ± 0.6†	7.6 ± 0.7†‡∥	6.9 ± 0.7	7.3 ± 0.5	7.4 ± 0.6	7.1 ± 0.6†	7.3 ± 0.5	6.9 ± 0.7

^*Each radioligand was tested 3 times in control baboon or different baboon lesioned previously with serotonergic neurotoxin MDMA.

^†Designates significant difference from control (ANOVA without correction for multiple comparisons).

^‡Designates significant difference from control (ANOVA with correction for multiple comparisons).

^∥Designates significant difference from MDMA (ANOVA without correction for multiple comparisons).

MB = midbrain; Hypo = hypothalamus; Put = putamen; Cd = caudate; FC = frontal cortex; PC = parietal cortex; TC = temporal cortex; CC = cingulate cortex; OC = occipital cortex; Cereb = cerebellum.

Values represent mean ± SD (n = 3).