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. Author manuscript; available in PMC: 2007 Nov 15.
Published in final edited form as: J Nucl Med. 2002 May;43(5):678–692.

TABLE 3.

Regional K1 Values After Injection of (+)-11C-McN5652 or 11C-DASB

Radioligand* Pons MB Hypo Thalamus Put Cd FC PC TC CC OC Cereb
11C-McN5652
 Control 0.29 ± 0.03 0.24 ± 0.02 0.30 ± 0.04 0.28 ± 0.01 0.24 ± 0.02 0.22 ± 0.02 0.23 ± 0.02 0.27 ± 0.02 0.23 ± 0.01 0.23 ± 0.01 0.30 ± 0.02 0.29 ± 0.02
 MDMA 0.26 ± 0.04 0.25 ± 0.02 0.27 ± 0.02 0.28 ± 0.02 0.26 ± 0.02 0.21 ± 0.02 0.25 ± 0.05 0.31 ± 0.03 0.23 ± 0.02 0.29 ± 0.02 0.35 ± 0.03 0.30 ± 0.01
 Paroxetine 0.27 ± 0.04 0.25 ± 0.05 0.30 ± 0.06 0.30 ± 0.07 0.32 ± 0.10 0.29 ± 0.08 0.24 ± 0.03 0.28 ± 0.04 0.21 ± 0.04 0.25 ± 0.06 0.30 ± 0.06 0.29 ± 0.05
11C-DASB
 Control 0.35 ± 0.02 0.30 ± 0.04 0.36 ± 0.05 0.33 ± 0.04 0.29 ± 0.01 0.27 ± 0.02 0.26 ± 0.03 0.31 ± 0.05 0.27 ± 0.04 0.27 ± 0.04 0.34 ± 0.03 0.37 ± 0.06
 MDMA 0.30 ± 0.05 0.28 ± 0.02 0.32 ± 0.04 0.31 ± 0.05 0.28 ± 0.02 0.24 ± 0.02 0.27 ± 0.06 0.33 ± 0.06 0.24 ± 0.02 0.30 ± 0.05 0.37 ± 0.05 0.34 ± 0.06
 Paroxetine 0.39 ± 0.05 0.36 ± 0.05 0.43 ± 0.08 0.42 ± 0.03 0.46 ± 0.06† 0.46 ± 0.06† 0.35 ± 0.05 0.39 ± 0.05 0.27 ± 0.02 0.37 ± 0.03 0.42 ± 0.05 0.47 ± 0.06
*

Each radioligand was tested 3 times in control baboon or different baboon lesioned previously with serotonergic neurotoxin MDMA.

†

Designates significant difference from control (ANOVA without correction for multiple comparisons).

MB = midbrain; Hypo = hypothalamus; Put = putamen; Cd = caudate; FC = frontal cortex; PC = parietal cortex; TC = temporal cortex; CC = cingulate cortex; OC = occipital cortex; Cereb = cerebellum.

Values represent mean ± SD (n = 3).