TABLE 4.

Regional k₂ Values After Injection of (+)-¹¹C-McN5652 or ¹¹C-DASB

Radioligand*	Pons	MB	Hypo	Thalamus	Put	Cd	FC	PC	TC	CC	OC	Cereb
11C-McN5652
Control	0.10 ± 0.00	0.06 ± 0.00	0.07 ± 0.01	0.08 ± 0.01	0.10 ± 0.00	0.10 ± 0.02	0.18 ± 0.01	0.19 ± 0.01	0.15 ± 0.01	0.15 ± 0.01	0.21 ± 0.02	0.21 ± 0.02
MDMA	0.15 ± 0.04†	0.11 ± 0.03†	0.13 ± 0.02†	0.19 ± 0.01†	0.24 ± 0.02†	0.18 ± 0.02†	0.30 ± 0.03†	0.36 ± 0.03†	0.23 ± 0.01†	0.32 ± 0.03†	0.42 ± 0.02†	0.35 ± 0.03†
Paroxetine	0.19 ± 0.04†	0.17 ± 0.02†‡	0.20 ± 0.03†	0.18 ± 0.02†	0.18 ± 0.01†	0.17 ± 0.01†	0.18 ± 0.03‡	0.20 ± 0.03‡	0.14 ± 0.01‡	0.19 ± 0.02‡	0.21 ± 0.02‡	0.23 ± 0.03‡
11C-DASB
Control	0.08 ± 0.03	0.05 ± 0.02	0.05 ± 0.01	0.07 ± 0.02	0.13 ± 0.03	0.10 ± 0.01	0.28 ± 0.07	0.34 ± 0.04	0.24 ± 0.03	0.24 ± 0.05	0.38 ± 0.06	0.40 ± 0.04
MDMA	0.11 ± 0.02	0.09 ± 0.00†	0.11 ± 0.02†	0.20 ± 0.00†	0.31 ± 0.03†	0.22 ± 0.02†	0.45 ± 0.09	0.56 ± 0.07	0.34 ± 0.04†	0.43 ± 0.06†	0.61 ± 0.03†	0.53 ± 0.05
Paroxetine	0.51 ± 0.03†‡	0.45 ± 0.02†‡	0.54 ± 0.02†‡	0.52 ± 0.03†‡	0.59 ± 0.06†‡	0.61 ± 0.06†‡	0.51 ± 0.05	0.54 ± 0.05	0.37 ± 0.03	0.52 ± 0.04†	0.58 ± 0.06	0.68 ± 0.04†

^*Each radioligand was tested 3 times in control baboon or different baboon lesioned previously with serotonergic neurotoxin MDMA.

^†Designates significant difference from control (ANOVA without correction for multiple comparisons).

^‡Designates significant difference from control (ANOVA with correction for multiple comparisons).

MB = midbrain; Hypo = hypothalamus; Put = putamen; Cd = caudate; FC = frontal cortex; PC = parietal cortex; TC = temporal cortex; CC = cingulate cortex; OC = occipital cortex; Cereb = cerebellum.

Values represent k₂ × 10 (mean ± SD [n = 3]).