Figure 2.

Effects of high valproate (2 mM) and high lithium (25 mM) concentrations separately and in combination on extracellular glutamate. Mouse cerebral cortex slices were prepared, restored, prelabeled, and incubated as described in Experimental Procedures and in Fig. 1. Glutamate levels in the media of drug-treated slices all differed significantly from the control (P < 0.001). The percent increase above the control is shown (control, glutamate = 106 ± 1 nM).