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. 1997 Apr 29;94(9):4761–4765. doi: 10.1073/pnas.94.9.4761

Figure 4.

Figure 4

LTP in fyn-rescue and young fyn-deficient mice and Src compensation in fyn-deficient mice. (A) Field EPSP recorded before and after tetanic stimulation in slices from adult wild-type (wt, ▪), fyn-deficient (fyn−, ▵), and fyn-rescue mice (fyn-rescue, ▴). Each point is the mean ± SEM of the field EPSP slope. Wild-type mice: n = 8 animals, 13 slices; fyn-deficient mice: n = 9 animals, 16 slices; fyn-rescue mice: n = 11 animals, 32 slices. (B) LTP measured 1 hr after tetanic stimulation. Wild-type (wt) mice: 148.3 ± 8.7% (n = 8); fyn-rescue (fyn-rescue) mice: 135.0 ± 7.2% (n = 9); fyn-deficient (fyn−) mice: 112.7 ± 5.7% (n = 11). Wild-type mice versus fyn-rescue mice: t = 1.14, not significant; fyn-rescue mice versus fyn-deficient mice: t = 2.39, P < 0.05. (C) Time course of LTP in wild-type (wt, •) and fyn-deficient (fyn−, □) mice. Each point is the percentage of LTP obtained at different age. Wild-type mice: 2 weeks, n = 5; 6 weeks, n = 6; 10 weeks, n = 6; 14 weeks, n = 9. fyn-deficient mice: 2 weeks, n = 12; 6 weeks, n = 7; 10 weeks, n = 4, 14 weeks, n = 6. (D) Src levels in wild-type (wt) and fyn-deficient (fyn) mice of different postnatal ages. Protein extract from mice aged 2, 6, 10, 12, and 14 weeks. The levels of Src are indicated by the arrow.