Table 3.
Description of Dagestan genetic isolates with aggregation of different psychiatric diseases and conditions
| Parameter |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Isolate code* | Ethnicity | isolation time† | coefficient of inbreeding‡ | population size | pedigree size§ | NAF (NRC)║ | NRC¶ | lifetime morbidity risk | mean age of onset of schizophrenia | condition |
| 6005† | Laks | 5000 | 0.0114 | 931 | 274 | 25 (19) | 40 | 0.0241 | 22.1 ± 1.95 | schizophrenia |
| 6004 | Laks | 5000 | 0.0115 | 1125 | 375 | 15 (12) | 28 | 0.0241 | 24.3 ± 2.20 | unipolar depression |
| 6007 | Tindals | 3000 | 0.0133 | 1800 | 539 | 36 (26) | 86 | 0.0176 | 24.0 ± 2.35 | schizophrenia |
| 6029 | Kumiks | 600 | 0.0017 | 2000 | 342 | 24 (18) | 43 | 0.0163 | 20.7 ± 1.61 | schizophrenia |
| 6010 | Dargins | 700 | 0.0066 | 2000 | 533 | 70 (24) | 50 | 0.0297 | 20.6 ± 1.95 | schizophrenia |
| 6022 | Dargins | 4000 | 0.0091 | 1340 | 314 | 20 (16) | 46 | 0.0271 | 20.8 ± 1.51 | schizophrenia |
| 6030 | Dargins | 3000 | 0.0110 | 700 | 257 | 28 (9) | 14 | 0.0495 | 24.5 ± 2.14 | schizophrenia |
| 6015 | Avars | 800 | 0.0099 | 1153 | 396 | 23 (21) | 43 | 0.0143 | 21.7 ± 2.05 | schizophrenia |
| 6006 | Avars | 3000 | 0.0112 | 1100 | 340 | 27 (16) | 42 | 0.0310 | 21.1 ± 1.95 | bipolar depression |
| 6011 | Dargins | 700 | 0.0066 | 2000 | 187 | 15 (11) | 26 | - | - | mental retardation |
*Codes given instead of the names of the villages for ethical reasons.
†Approximate isolation time of the populations known from archives, ancient publications and archeological data.
‡Estimated coefficient of inbreeding.
§Number of persons within a larger pedigree.
║NAF (NRC) – number of affected individuals in the pedigree (and number of affected individuals that were recruited in the study).
¶NRC – number of individuals from the pedigree recruited in the study for clinical (DIGS) and DNA sampling, regardless of their affection status.