Figure 3.
Inward high-voltage activated Ca2+ currents measured by patch-clamp recording in dissociated sensory neurons decrease after chronic constriction injury. (A) Sample currents elicited by square-wave voltage commands (bottom) are decreased in an injured neuron (middle) compared to a neuron from a control animal (top). (B) Current-voltage plot of average data for medium sized neurons shows a loss of peak current in injured neurons from animals with neuropathic pain. From Hogan et al (46), with permission.