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. Author manuscript; available in PMC: 2008 Aug 1.
Published in final edited form as: Curr Opin Neurobiol. 2007 Aug 13;17(4):490–497. doi: 10.1016/j.conb.2007.07.014

Figure 1.

Figure 1

Phylogenetic analysis of TRP channels. ThermoTRPs are indicated by blue (cold activated) and red (heat activated) circles. Human TRP amino acid sequences were used for the analysis with the exception of TRPC2 for which the mouse channel was used. Topology models are shown including several characteristic domains (predicted using http://www.ebi.ac.uk/InterProScan and/or indicated in [17,19,24,55]). TRPM2, TRPM4 and TRPM5 are temperature sensitive; however, evidence for their expression in DRG or skin is lacking [28,72].

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