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. Author manuscript; available in PMC: 2008 Aug 1.
Published in final edited form as: Curr Opin Neurobiol. 2007 Aug 13;17(4):490–497. doi: 10.1016/j.conb.2007.07.014

Table 1.

ThermoTRP Thermal activation Chemical agonist Sensory neuron/skin expression Temperature phenotype of null mutant
TRPV1 > 42°C capsaicin, acidic pH, camphor, ethanol, resiniferatoxin, 2-APB piperine, eugenol, gingerol, VaTx1-3 (spider toxin) sensory neuron impaired thermal avoidance and hyperalgesia
TRPV2 > 52°C 2-APB camphor, menthol, thymol, carvacrol, eugenol, 2-APB sensory neuron not reported
TRPV3 > 33°C keratinocytes/sensory neuron? impaired thermotaxis and thermal avoidance.
TRPV4 > 25–34°C 4αPDD, bisandrographolide keratinocytes/sensory neuron impaired thermotaxis, thermal avoidance, and hyperalgesia
TRPM2* > 35°C H2O2, ADP-ribose, βNAD not reported not reported
TRPM4* heat** cytosolic Ca2+ not reported not reported
TRPM5* heat** cytosolic Ca2+ not reported not reported
TRPM8 < 25°C menthol, icilin, l-carvone eucalyptol, isopulegol, geraniol, linalool sensory neuron impaired cold sensation
TRPA1 < 17°C cinnamaldehyde, mustard oil, eugenol, icilin, allicin, acrolein methyl salicylate, gingerol, GsMTx-4 (spider toxin), etc. sensory neuron
  • - impaired cold sensation [5]

  • - no thermal deficits observed [35]

*

TRPM2, TRPM4 and TRPM5 are temperature sensitive; however, evidence for their expression in DRG or skin is lacking [28,72]. The expression of TRPM5 in taste cells however suggests a potential explanation for the intriguing observation that temperature can affect taste perception [72].

**

Activity of TRPM4 and TRPM5 is increased by heating but thermal activation thresholds have not been determined.

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