TABLE 1.
Relative mitogenic activity of FGF subfamilies
FGF receptor | Relative mitogenic activity ± S.D.
|
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---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FGF-1 | FGF7 subfamily
|
FGF8 subfamily
|
FGF9 subfamily
|
FGF19 subfamily (×103)
|
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FGF7 | FGF10 | FGF22 | FGF8 | FGF17 | FGF18 | FGF9 | FGF16 | FGF20 | FGF19 | FGF21 | FGF23 | ||
1c | 100 ± 5 | 14.2 ± 4.1 | 12.5 ± 2.5 | 10.2 ± 1.7 | 57.5 ± 3.2 | 22.7 ± 0.3 | 4.7 ± 0.4 | 12.5 ± 1.4 | 4.3 ± 0.3 | 28.1 ± 4.0 | 123 ± 5.7 | 34 ± 3.0 | 23 ± 2.7 |
2c | 100 ± 3 | 10.4 ± 4.0 | 6.1 ± 1.7 | 7.1 ± 1.1 | 91.6 ± 8.9 | 27.1 ± 9.5 | 28.9 ± 4.7 | 57.2 ± 5.4 | 32.5 ± 3.5 | 68.4 ± 2.8 | 238 ± 11.5 | 86 ± 4.7 | 89 ± 10.5 |
3c | 100 ± 6 | 3.3 ± 1.4 | 0.8 ± 0.9 | 1.0 ± 0.5 | 209 ± 6 | 111 ± 5 | 77.7 ± 3.4 | 90.4 ± 6.0 | 32.4 ± 6.8 | 89.5 ± 7.3 | 140 ± 11.1 | 23 ± 02.3 | 43 ± 5.5 |
1b | 100 ± 4 | 8.0 ± 1.5 | 39.4 ± 1.3 | 40.3 ± 1.6 | 5.3 ± 0.4 | 6.0 ± 2.2 | 6.3 ± 1.1 | 7.3 ± 1.0 | 6.5 ± 1.1 | 7.3 ± 0.9 | 12 ± 0.5 | 19 ± 3.4 | 11 ± 2.4 |
2b | 100 ± 5 | 168 ± 6 | 217 ± 1 | 232 ± 3 | 5.9 ± 1.4 | 6.3 ± 0.6 | 7.8 ± 1.8 | 2.9 ± 0.4 | 1.8 ± 0.5 | 12.3 ± 0.7 | 61 ± 6.9 | 83 ± 5.4 | 66 ± 2.7 |
3b | 100 ± 4 | 6.7 ± 1.8 | 6.0 ± 0.5 | 5.3 ± 0.7 | 18.6 ± 6.3 | 10.7 ± 2.7 | 12.5 ± 2.0 | 42.7 ± 2.9 | 13 ± 2.6 | 44.3 ± 1.5 | 20 ± 1.7 | 26 ± 1.5 | 21 ± 0.8 |
4Δ | 100 ± 4 | 17.8 ± 0.5 | 11.5 ± 0.5 | 12.5 ± 0.9 | 102 ± 0.4 | 85.5 ± 1.1 | 52.8 ± 1.7 | 10.1 ± 0.1 | 9.9 ± 0.3 | 26.6 ± 0.9 | 410 ± 27.7 | 128 ± 9.6 | 222 ± 11.9 |