Table 1. Characteristics of NSCLC Cell Lines.
Cell Line | EGFR | Gefitinib IC50 | Ras |
H1299 | WT | 38.0 µM | N-RasQ61K |
H1819 | WT | 4.7 µM | WT |
H460 | WT | 8.0 µM | K-RasQ61H |
H1975 | L858R, T790M | 1.9 µM | WT |
HCC2279 | Δ746–750 | 5.0 µM | WT |
H3255 | L858R | 9.0 nM | WT |
H4006 | Δ746–750 | 30.0 nM | WT |
HCC827 | Δ746–750 | 16.0 nM | WT |
Abbreviations: WT, wild-type; IC50 , 50% inhibitory concentration Gefitinib IC50 values have been reported (Fujimoto et al., 2005).