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. 2007 Sep 14;8:340. doi: 10.1186/1471-2105-8-340

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Copyright © 2007 Hill et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Examples of segmentation-sensitive and resistant cell-body features. Panels (A, B) show dose response of the KS statistic to the compound 17AAG, for the P2A feature in Channel 1, computed using only well-segmented cells (A), or only poorly segmented cells (B). A substantial difference is seen between the two responses for this "sensitive" feature. Panels (C, D) show dose response of KS statistic to the compound 5-FU, for the Average Intensity feature in Channel 3, computed using only well-segmented cells (C), or only poorly segmented cells (D). The two dose responses are similar for this "resistant" feature.