Table 3.

Sensitivity of compound-feature combinations to cell segmentation

		Resistant	Sensitive	Overall Sensitive %
Channel	Feature Type
Ch1	arrangement	24	16	58%
	dimension	16	94
	intensity	32	18
	shape	33	27
	texture	14	6
Ch2	intensity	19	1	5%
Ch3	arrangement	6	14	47%
	intensity	36	14
	texture	26	33
Ch4	arrangement	10	20	46%
	dimension	7	3
	intensity	57	33
	shape	2	8
	texture	32	28

The dose response of each feature for each drug was fitted by a linear model, using either the well-segmented cell population, or the poorly-segmented cell population. The discrepancy between the well- and poorly- segmented dose responses was calculated for each drug-feature combination, and drug-feature combinations were then binned as either sensitive to segmentation (if the discrepancy was larger than the grand median discrepancy) or resistant to segmentation (if the discrepancy was smaller than the grand median).