Figure 5. cyp26a1 Is Required Outside of the Anterior Neural Domain.

(A and D) hoxb1b expression in wild-type (wt) embryos.

(A–C′) Lateral view, anterior to top, dorsal to right.

(D–F′) Dorsal view, anterior to top.

(B, C′, E, and F′) Merged brightfield and fluorescent images show positions of transplanted cyp26a1-deficient cells labeled with lysine-fixable rhodamine dextran (red).

(B–C′) Transplants of cyp26a1-deficient cells located within the endogenous hoxb1b domain cause a nearly cell-autonomous decrease in hoxb1b expression (black arrowheads).

(E–F′) Transplants of cyp26a1-deficient cells also cause changes in hoxb1b expression in adjacent host cells (white arrowheads).