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. Author manuscript; available in PMC: 2007 Nov 19.
Published in final edited form as: Lancet. 2007 Mar 24;369(9566):1000–1015. doi: 10.1016/S0140-6736(07)60460-7

Table 2.

Dose taken by adults at withdrawal or last follow-up

Carbamazepine Gabapentin Lamotrigine Topiramate Oxcarbazepine *
Inadequate seizure control n=33 n=83 n=42 n=40 n=15
991 (347); 400–1800 2414 (899); 300–4800 355 (175); 85–800 291 (168); 50–600 1480 (525); 300–2100
Unacceptable adverse events n=50 n=35 n=30 n=68 n=29
546 (189); 200–1000 1366 (636); 400–3000 178 (113); 25–550 137 (77); 25–400  895 (351); 300–2100
Inadequate seizure control and unacceptable
adverse events
n=18 n=23 n=9 n=16  n=9
711 (323); 200–1400 1878 (875); 600–3600 219 (178); 50–550 218 (110); 75–400 1150 (525); 450–1950
Other reason for withdrawal n=13 n=14 n=19 n=14  n=7
569 (317); 200–1200 1314 (466); 300–2100 184 (62); 50–300 189 (103); 75–500  814 (285); 600–1200
Remission of seizures n=14 n=12 n=9 n=13  n=7
614 (337); 200–1400 1475 (663); 300–2700 158 (92); 50–300 133 (57); 50–200  771 (293); 300–1200
Still on randomised drug n=140 n=120 n=168 n=126 n=87
662 (311); 100–2000 1496 (669); 300–3600 249 (136); 20–800 181 (108); 25–600 1019 (467); 300–2850

Data are mean (SD); range.

*

Figures in this column use data only for patients randomised after June 1, 2001.