Table 2.
Carbamazepine | Gabapentin | Lamotrigine | Topiramate | Oxcarbazepine * | |
---|---|---|---|---|---|
Inadequate seizure control | n=33 | n=83 | n=42 | n=40 | n=15 |
991 (347); 400–1800 | 2414 (899); 300–4800 | 355 (175); 85–800 | 291 (168); 50–600 | 1480 (525); 300–2100 | |
Unacceptable adverse events | n=50 | n=35 | n=30 | n=68 | n=29 |
546 (189); 200–1000 | 1366 (636); 400–3000 | 178 (113); 25–550 | 137 (77); 25–400 | 895 (351); 300–2100 | |
Inadequate seizure control and unacceptable adverse events |
n=18 | n=23 | n=9 | n=16 | n=9 |
711 (323); 200–1400 | 1878 (875); 600–3600 | 219 (178); 50–550 | 218 (110); 75–400 | 1150 (525); 450–1950 | |
Other reason for withdrawal | n=13 | n=14 | n=19 | n=14 | n=7 |
569 (317); 200–1200 | 1314 (466); 300–2100 | 184 (62); 50–300 | 189 (103); 75–500 | 814 (285); 600–1200 | |
Remission of seizures | n=14 | n=12 | n=9 | n=13 | n=7 |
614 (337); 200–1400 | 1475 (663); 300–2700 | 158 (92); 50–300 | 133 (57); 50–200 | 771 (293); 300–1200 | |
Still on randomised drug | n=140 | n=120 | n=168 | n=126 | n=87 |
662 (311); 100–2000 | 1496 (669); 300–3600 | 249 (136); 20–800 | 181 (108); 25–600 | 1019 (467); 300–2850 |
Data are mean (SD); range.
Figures in this column use data only for patients randomised after June 1, 2001.