Table 3 Multivariate regression model evaluating the predictors of CRP levels in the COPD cohort.
| Parameter estimate | SE | Type III SS | Significance | |
|---|---|---|---|---|
| Age | −0.02 | 0.01 | 1.38 | 0.009 |
| Sex | −0.16 | 0.10 | 0.51 | 0.107 |
| Pack years | 0.18 | 0.12 | 0.43 | 0.141 |
| BMI | 0.04 | 0.01 | 2.84 | <0.001 |
| FEV1 (% predicted) | 0.81 | 0.43 | 0.67 | 0.065 |
| 6MWT | −1.14 | 0.44 | 1.29 | 0.012 |
| COPD exacerbation history | −0.16 | 0.10 | 0.52 | 0.106 |
SE, standard error for the parameter estimate; SS, sum of squares; BMI, body mass index; FEV1, forced expiratory volume in 1 second; 6MWT, 6 minute walk test.
All of the effects were examined simultaneously (that is, the magnitude of each main effect or interaction was examined after controlling for all the other main effects and interactions).
The total sum of squares was 6.83; R2 estimate = 0.31.
The following variables were included in the full model but excluded because they failed the significance limit (p<0.15): history of IHD, Tlco % predicted, SGRQ composite score.